P06756 | AlphaKnot 2.0

AF6

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Information

Protein name	Integrin alpha-V
Main knot	3₁ (85%)
Global pLDDT	88.3
Species	Human
UniProt	P06756
Structure Prediction Model	AlphaFold v6: P06756
PDB structures	-
Structure in AlphaLasso	P06756: LL_-4,-3 L₀
Model length	1048
AlphaFold deposition date	2026-06-01
AlphaKnot deposition date	2026-07-09

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Knot types & Model sequence

					Knot pLDDT	Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Main Knot
					79.07	801-929	129	1-800, 930-1048	800	119		Knot

Model Sequence

MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET

Comments

AF4

Categories voted by users:

Information

Protein name	Integrin alpha-V
Main knot	3₁ (85%)
Global pLDDT	88.19
Species	Human
UniProt	P06756
Structure Prediction Model	AlphaFold v4: P06756
PDB structures	1JV2 A 1L5G A 1M1X A 1U8C A 3IJE A 4G1E A 4G1M A 4MMX A 4MMY A 4MMZ A 4O02 A 4UM8 A/C 4UM9 A/C 5FFG A 5FFO A/E 5NEM A 5NER A 5NET A 5NEU A 6AVQ A 6AVR A 6AVU A 6DJP A 6MK0 A 6MSL A 6MSU A 6NAJ A 6OM1 A/C/E/G 6OM2 A/C 6UJA A 6UJB A 6UJC A 7Y1T A
Structures in KnotProt	1JV2 A, Artifact S +3.1: 31-987 1L5G A, Artifact S +3.1: 31-987 1M1X A, Artifact K +3.1: 31-987 1U8C A, Artifact S +3.1: 31-987 3IJE A, Artifact K +3.1: 31-997 4G1E A, Artifact K +3.1, +3.1, 4.1, +3.1, +3.1: 31-989 4G1M A, Artifact K 4.1, +3.1: 31-989 4MMX A, Artifact S +3.1: 31-989 4MMY A, Artifact K +3.1: 31-989 4MMZ A, Artifact K +3.1: 31-989 6AVQ A, -3.1: 31-987 6AVR A, -3.1: 31-987 6AVU A, -3.1: 31-987
Structure in AlphaLasso	P06756: LL_-4,-3 L₀
Model length	1048
AlphaFold deposition date	2022-06-01
AlphaKnot deposition date	2023-01-27

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Knot types & Model sequence

					Knot pLDDT	Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Main Knot
					88.7	378-912	535	1-377, 913-1048	377	136

Model Sequence

Comments

AF1-Unsure

Categories voted by users:

Information

Protein name	Integrin alpha-V
Main knot	3₁ (88%)
Knot fingerprint	K 3₁ 3₁ 4₁ 3₁ 3₁
Global pLDDT	88.3
Species	Human
UniProt	P06756
Structure Prediction Model	AlphaFold v1: P06756
PDB structures	1JV2 A 1L5G A 1M1X A 1U8C A 3IJE A 4G1E A 4G1M A 4MMX A 4MMY A 4MMZ A 4O02 A 4UM8 A/C 4UM9 A/C 5FFG A 5FFO A/E 5NEM A 5NER A 5NET A 5NEU A 6AVQ A 6AVR A 6AVU A 6DJP A 6MK0 A 6MSL A 6MSU A 6NAJ A 6OM1 A/C/E/G 6OM2 A/C 6UJA A 6UJB A 6UJC A 8IJ5 E 8TCF A 8TCG A 8VS6 A 8VSD A 8W30 A 8XEI A 8XEK A 8XEL A 8XEN A 8XER A 8XEZ A 8XF6 A 8XFG A 8XFO A 9CZ7 A 9CZA A 9CZD A 9CZF A 9IND A 9IUJ A 9JEI A 8ZDF A 8ZDG A
Structures in KnotProt	1JV2 A, Artifact S +3.1: 31-987 1L5G A, Artifact S +3.1: 31-987 1M1X A, Artifact K +3.1: 31-987 1U8C A, Artifact S +3.1: 31-987 3IJE A, Artifact K +3.1: 31-997 4G1E A, Artifact K +3.1, +3.1, 4.1, +3.1, +3.1: 31-989 4G1M A, Artifact K 4.1, +3.1: 31-989 4MMX A, Artifact S +3.1: 31-989 4MMY A, Artifact K +3.1: 31-989 4MMZ A, Artifact K +3.1: 31-989 6AVQ A, -3.1: 31-987 6AVR A, -3.1: 31-987 6AVU A, -3.1: 31-987
Structure in AlphaLasso	P06756: LL_-4,-3 L₀
Model length	1048
AlphaFold deposition date	2021-07-01
AlphaKnot deposition date	2021-12-18

Knot map

Knot cutoff: 48%

Help Knotting data interpretation

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Knot types & Model sequence

					Knot pLDDT	Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Main Knot
					77.4	780-979	200	1-779, 980-1048	779	69		Knot
					80.2	804-955	152	1-803, 956-1048	803	93		Slipknot

Model Sequence

Comments

Domain	Eukaryota
Family	Hominidae
Species (Full Name)	Homo sapiens
PFAM codes	PF00357, PF01839, PF08441
InterPro codes	IPR000413, IPR013517, IPR013519, IPR013649, IPR018184, IPR028994, IPR032695
PDB structures (whole Protein)	1JV2 A: 31-987 1L5G A: 31-987 1M1X A: 31-987 1U8C A: 31-987 3IJE A: 31-997 4G1E A: 31-989 4G1M A: 31-989 4MMX A: 31-989 4MMY A: 31-989 4MMZ A: 31-989 4O02 A: 31-992 4UM8 A/C: 31-625 4UM9 A/C: 31-625 5FFG A: 31-625 5FFO A/E: 31-625 5NEM A: 31-624 5NER A: 31-624 5NET A: 31-624 5NEU A: 31-624 6AVQ A: 31-987 6AVR A: 31-987 6AVU A: 31-987 6DJP A: 31-995 6MK0 A: 31-984 6MSL A: 31-997 6MSU A: 31-997 6NAJ A: 31-984 6OM1 A/C/E/G: 31-624 6OM2 A/C: 31-624 6UJA A: 31-1048 6UJB A: 31-1048 6UJC A: 31-1048 7Y1T A: 1-625 8IJ5 E: 31-623 8TCF A: 31-473 8TCG A: 31-469 8VS6 A: 31-992 8VSD A: 31-623 8W30 A: 31-625 8XEI A: 1-1048 8XEK A: 1-1048 8XEL A: 1-1048 8XEN A: 1-1048 8XER A: 1-1048 8XEZ A: 1-1048 8XF6 A: 1-1048 8XFG A: 1-1048 8XFO A: 1-1048 9CZ7 A: 31-625 9CZA A: 31-625 9CZD A: 31-625 9CZF A: 31-625 9IND A: 31-470 9IUJ A: 31-987 9JEI A: 31-987 8ZDF A: 1-1048 8ZDG A: 1-1048

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P06756F1

AF6

Model Sequence

AF4

Model Sequence

AF1-Unsure

Model Sequence