P31153 | AlphaKnot 2.0

AF4

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Information

Protein name	S-adenosylmethionine synthase isoform type-2
Main knot	3₁ (71%)
Global pLDDT	96.22
Species	Human
UniProt	P31153
Structure Prediction Model	AlphaFold v4: P31153
PDB structures	2P02 A 4KTT A/B/C/D 4KTV A/B/C/D 4NDN A/B/C/D 5A19 A 5A1G A 5A1I A 5UGH A/B/C/D 6FAJ A/B 6FBN A/B 6FBO A 6FBP A/B 6FCB A 6FCD A 6FWB A/B/C/D 6G6R A 6P9V A 6WKB A/B 7BHR A 7BHS A 7BHT A 7BHU A 7BHV A 7BHW A 7BHX A 7KCC A 7KCE A 7KCF A 7KDA A 7KDB A 7L1A A 7LNH A/B 7RW5 A/B/C/D 7RW7 A 7RWG A 7RWH A 7RXV A 7RXW A 7RXX A
Structures in KnotProt	2P02 A, K +3.1: 1-395 4KTT A/B/C/D, K +3.1: 1-395 4KTV A/B/C/D, K +3.1: 1-395 4NDN A/B/C/D, K +3.1: 1-395 5A19 A, K +3.1: 1-395 5A1G A, K +3.1: 1-395 5A1I A, K +3.1: 1-395 5UGH A/B/C/D, K +3.1, +3.1: 1-395 6FAJ A/B, +3.1: 1-395 6FBN A/B, +3.1: 1-395 6FBO A, +3.1: 1-395 6FBP A/B, +3.1: 1-395 6FCB A, +3.1: 1-395 6FCD A, +3.1: 1-395 6FWB A/B/C/D, +3.1: 1-394 6G6R A, +3.1: 1-395 6P9V A, +3.1: 1-395 6WKB A/B, +3.1: 1-395 7BHR A, +3.1: 1-395 7BHS A, +3.1: 1-395 7BHT A, +3.1: 1-395 7BHU A, +3.1: 1-395 7BHV A, +3.1: 1-395 7BHW A, +3.1: 1-395 7BHX A, +3.1: 1-395 7KCC A, +3.1: 1-395 7KCE A, +3.1: 1-395 7KCF A, +3.1: 1-395 7KDA A, +3.1: 1-395 7KDB A, +3.1: 1-395 7L1A A, +3.1: 1-395
Model length	395
AlphaFold deposition date	2022-06-01
AlphaKnot deposition date	2023-01-27

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Knot types & Model sequence

					Knot pLDDT	Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Main Knot
					97.6	26-282	257	1-25, 283-395	25	113

Model Sequence

MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY

Comments

AF1-Knot

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Information

Protein name	S-adenosylmethionine synthase isoform type-2
Main knot	3₁ (66%)
Knot fingerprint	K 3₁
Global pLDDT	96.2
Species	Human
UniProt	P31153
Structure Prediction Model	AlphaFold v1: P31153
PDB structures	2P02 A 4KTT A/B/C/D 4KTV A/B/C/D 4NDN A/B/C/D 5A19 A 5A1G A 5A1I A 5UGH A/B/C/D 6FAJ A/B 6FBN A/B 6FBO A 6FBP A/B 6FCB A 6FCD A 6FWB A/B/C/D 6G6R A 6P9V A 6WKB A/B 7BHR A 7BHS A 7BHT A 7BHU A 7BHV A 7BHW A 7BHX A 7KCC A 7KCE A 7KCF A 7KDA A 7KDB A 7L1A A
Structures in KnotProt	2P02 A, K +3.1: 1-395 4KTT A/B/C/D, K +3.1: 1-395 4KTV A/B/C/D, K +3.1: 1-395 4NDN A/B/C/D, K +3.1: 1-395 5A19 A, K +3.1: 1-395 5A1G A, K +3.1: 1-395 5A1I A, K +3.1: 1-395 5UGH A/B/C/D, K +3.1, +3.1: 1-395 6FAJ A/B, +3.1: 1-395 6FBN A/B, +3.1: 1-395 6FBO A, +3.1: 1-395 6FBP A/B, +3.1: 1-395 6FCB A, +3.1: 1-395 6FCD A, +3.1: 1-395 6FWB A/B/C/D, +3.1: 1-394 6G6R A, +3.1: 1-395 6P9V A, +3.1: 1-395 6WKB A/B, +3.1: 1-395 7BHR A, +3.1: 1-395 7BHS A, +3.1: 1-395 7BHT A, +3.1: 1-395 7BHU A, +3.1: 1-395 7BHV A, +3.1: 1-395 7BHW A, +3.1: 1-395 7BHX A, +3.1: 1-395 7KCC A, +3.1: 1-395 7KCE A, +3.1: 1-395 7KCF A, +3.1: 1-395 7KDA A, +3.1: 1-395 7KDB A, +3.1: 1-395 7L1A A, +3.1: 1-395
Model length	395
AlphaFold deposition date	2021-07-01
AlphaKnot deposition date	2021-12-18

Knot map

Knot cutoff: 48%

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Knot types & Model sequence

					Knot pLDDT	Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Main Knot
					97.6	26-280	255	1-25, 281-395	25	115

Model Sequence

Comments

ESM1

Categories voted by users:

Information

Protein name	S-adenosylmethionine synthase isoform type-2
Main knot	3₁ (80%)
Global pLDDT	85.1
Species	Human
UniProt	P31153
Structure Prediction Model	ESM v1: esmfold_v1 - nov. 2022
PDB structures	2P02 A 4KTT A/B/C/D 4KTV A/B/C/D 4NDN A/B/C/D 5A19 A 5A1G A 5A1I A 5UGH A/B/C/D 6FAJ A/B 6FBN A/B 6FBO A 6FBP A/B 6FCB A 6FCD A 6FWB A/B/C/D 6G6R A 6P9V A 6WKB A/B 7BHR A 7BHS A 7BHT A 7BHU A 7BHV A 7BHW A 7BHX A 7KCC A 7KCE A 7KCF A 7KDA A 7KDB A 7L1A A 7LNH A/B 7RW5 A/B/C/D 7RW7 A 7RWG A 7RWH A 7RXV A 7RXW A 7RXX A
Structures in KnotProt	2P02 A, K +3.1: 1-395 4KTT A/B/C/D, K +3.1: 1-395 4KTV A/B/C/D, K +3.1: 1-395 4NDN A/B/C/D, K +3.1: 1-395 5A19 A, K +3.1: 1-395 5A1G A, K +3.1: 1-395 5A1I A, K +3.1: 1-395 5UGH A/B/C/D, K +3.1, +3.1: 1-395 6FAJ A/B, +3.1: 1-395 6FBN A/B, +3.1: 1-395 6FBO A, +3.1: 1-395 6FBP A/B, +3.1: 1-395 6FCB A, +3.1: 1-395 6FCD A, +3.1: 1-395 6FWB A/B/C/D, +3.1: 1-394 6G6R A, +3.1: 1-395 6P9V A, +3.1: 1-395 6WKB A/B, +3.1: 1-395 7BHR A, +3.1: 1-395 7BHS A, +3.1: 1-395 7BHT A, +3.1: 1-395 7BHU A, +3.1: 1-395 7BHV A, +3.1: 1-395 7BHW A, +3.1: 1-395 7BHX A, +3.1: 1-395 7KCC A, +3.1: 1-395 7KCE A, +3.1: 1-395 7KCF A, +3.1: 1-395 7KDA A, +3.1: 1-395 7KDB A, +3.1: 1-395 7L1A A, +3.1: 1-395
Model length	395
ESM generation time	2023-06-24: download the generated 3D model
AlphaKnot deposition date	2023-06-28

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Knot types & Model sequence

					Knot pLDDT	Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Main Knot
					73.9	26-286	261	1-25, 287-395	25	109

Model Sequence

Comments

Domain	Eukaryota
Family	Hominidae
Species (Full Name)	Homo sapiens
PFAM codes	PF00438, PF02772, PF02773
InterPro codes	IPR002133, IPR022628, IPR022629, IPR022630, IPR022631, IPR022636
PDB structures (whole Protein)	2P02 A: 1-395 4KTT A/B/C/D: 1-395 4KTV A/B/C/D: 1-395 4NDN A/B/C/D: 1-395 5A19 A: 1-395 5A1G A: 1-395 5A1I A: 1-395 5UGH A/B/C/D: 1-395 6FAJ A/B: 1-395 6FBN A/B: 1-395 6FBO A: 1-395 6FBP A/B: 1-395 6FCB A: 1-395 6FCD A: 1-395 6FWB A/B/C/D: 1-394 6G6R A: 1-395 6P9V A: 1-395 6WKB A/B: 1-395 7BHR A: 1-395 7BHS A: 1-395 7BHT A: 1-395 7BHU A: 1-395 7BHV A: 1-395 7BHW A: 1-395 7BHX A: 1-395 7KCC A: 1-395 7KCE A: 1-395 7KCF A: 1-395 7KDA A: 1-395 7KDB A: 1-395 7L1A A: 1-395 7LNH A/B: 1-395 7RW5 A/B/C/D: 1-395 7RW7 A: 1-395 7RWG A: 1-395 7RWH A: 1-395 7RXV A: 1-395 7RXW A: 1-395 7RXX A: 1-395 8AXZ A: 1-395 8OOG A: 1-395 8P1T AAA: 2-395 8P1V AAA: 2-395 8P1W AAA: 2-395 8P4H A/B/C/D: 2-395 8QDY A: 1-395 8QDZ A: 1-395 8QE0 A: 1-395 8QE1 A: 1-395 8QE2 A: 1-395 8QE3 A: 1-395 8XAM A/B: 16-395 8XAR A: 1-395 8XB0 A: 1-395 8XJ2 A/B/C/D: 1-395

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similar chains with experimentally solved models not found in AlphaKnot 2.0 database but found in thePDB database (?% sequence similarity)

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P31153F1

AF4

Model Sequence

AF1-Knot

Model Sequence

ESM1

Model Sequence