Q8WZ42 | AlphaKnot 2.0

AF1-Artifact

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Information

Protein name	Titin
Main knot	3₁ (70%)
Knot fingerprint	K 3₁ 3₁ 3₁
Global pLDDT	84.8
Species	Human
UniProt	Q8WZ42
Structure Prediction Model	AlphaFold v1: Q8WZ42
PDB structures	1TIT A 1TIU A 1WAA A/B/C/D/E/F 2RQ8 A 6I0Y z
Model length	1400
AlphaFold deposition date	2021-07-01
AlphaKnot deposition date	2021-12-18

Knot map

Knot cutoff: 48%

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Knot types & Model sequence

					Knot pLDDT	Knot core range	Knot core length	Knot tails range	N-end length	C-end length	Main Knot
					86.2	47-1208	1162	1-46, 1209-1400	46	192

Model Sequence

KGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELNKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREVELLKPIEDVTIYEKESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFECVLTREANVIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVSKDVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELSHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISEDDIHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKNLANIE

Knotting comparison of models

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Comments

Domain	Eukaryota
Family	Hominidae
Species (Full Name)	Homo sapiens
PDB structures (whole Protein)	1BPV A: 22283-22385 1G1C A/B: 2073-2171 1NCT A: 33483-33579 1NCU A: 33483-33579 1TIT A: 12680-12765 1TIU A: 12680-12765 1TKI A/B: 32172-32492 1TNM A: 33489-33579 1TNN A: 33489-33579 1WAA A/B/C/D/E/F: 12677-12765 1YA5 A/B: 1-196 2A38 A/B/C: 1-194 2BK8 A: 32497-32590 2F8V A/B/C/D: 1-196 2ILL A: 31854-32047 2J8H A: 31854-32047 2J8O A/B: 31854-32047 2NZI A/B: 31854-32155 2RQ8 A: 12677-12765 2WP3 T: 34252-34350 2WWK T: 34252-34350 2WWM D/T: 34252-34350 2Y9R T: 34252-34350 3B43 A: 7945-8511 3KNB A: 34253-34350 3LCY A/B/C/D: 31456-31649 3LPW A/B: 22877-23070 3PUC A: 33774-33871 3Q5O A/B: 34253-34350 3QP3 A/B/C: 33294-33395 4C4K T: 34252-34350 4JNW A/B: 32172-32492 4O00 A/B: 14217-14319 4QEG A: 2880-2967 4UOW 1/3/5/7/9/B/D/F/H/J/L/N/P/R/T/V/X/Z: 7-99 5BS0 C: 24337-24345 5JDD A: 2795-3053 5JDE A/B: 2795-3053 5JDJ A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P: 2880-2967 5JOE A: 9582-9671 6DL4 A: 1821-1931 6H4L A: 33294-33395 6HCI A/B/C/D: 32712-32816 6I0Y z: 12677-12765 6SDB A/B/C/D/E: 3-196 6YGN A/B: 32046-32594 7AHS A/B/C/D: 9582-9851 7NIP A: 9504-9544

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similar chains with experimentally solved models (PDB) in the AlphaKnot 2.0 database (?% sequence similarity)

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similar chains with experimentally solved models not found in AlphaKnot 2.0 database but found in thePDB database (?% sequence similarity)

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        #similar chains with experimentally solved models not found in AlphaKnot 2.0 database but found in the pdb database (?% sequence similarity)
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Q8WZ42F61

AF1-Artifact

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Model Sequence